Desenvolvimento de estruturas híbridas quitosana/fenitoína para o controle das crises epilépticas.

Abstract

Epilepsy report is relatively common disease in the population generates, due to various neurological disorders characterized by periodic and spontaneous occurrence of highly synchronized neuronal activity and behavioral manifestations. Only manifestation of crisis, although the principle can not be cataloged as epilepsy, requires clinical monitoring, research through specific complementary tests for each case, because of the risk of recurrence . Among the medications used to control seizures, phenytoin , is a major antiepileptic drugs , used both outpatient and in emergencies / urgencies . The proposal is to develop a material for monitoring, fast and accurate serum phenytoin in patients taking this medication, aiming to individualize the dosimetry and therefore greater therapeutic success. To meet the objectives mentioned above, was initially synthesized a membrane of chitosan with the incorporation of this drug (phenytoin) and made the most pertinent characterizations (OM, XRD, SEM , FTIR , DSC , biodegradation test , Surface Tension and cytotoxicity test) and analyzed the reactions of this front at different levels of pH membrane.