Estudo da solubilização do cetoconazol por microemulsão para incorporação em xampu.

Abstract

Mycotic infections affecting humans present themselves primarily as superficial mycoses and systemic mycoses. Superficial mycoses in turn, can manifest itself in various parts of the body, including the scalp, dandruff and seborrheic dermatitis, related to the fungus Malassezia furfur, are among the most prevalent. Among the drugs used to treat, there is ketoconazole, a imidazole derivative that acts by inhibiting ergosterol biosynthesis, exerting a fungicide. The ketoconazole shampoos are among the most dosage forms used to treat such infections. Advances in technology have produced innovative pharmaceutical drug carrier systems in order to increment release, distribution and/or dissolution of active principles, among which stands out the Microemulsions, systems that are transparent and thermodynamically stable liquid of two immiscible liquids stabilized by agents surfactants and co-surfactants. This work was focused on study of the solubility of ketoconazole microemulsions for incorporation into shampoo. The methodology used for the microemulsion systems and construction of the pseudo-ternary phase diagram consisted of using 90% of the surfactant mixture PEG 400/Ethanol cosurfactant, 4% soybean oil as the oil phase and 6% distilled water as the aqueous phase. Shampoo base formulations, shampoo base with ketoconazole and ketoconazole microemulsion shampoo were manipulated and evaluated for sensory characteristics, pH and viscosity, satisfactory results for these parameters. The active shampoo base determination and the incorporation rate of ketoconazole shampoo in the microemulsions and microemulsion was performed in UV-Vis spectrophotometry methodology being properly validated. It is an incorporation rate of ketoconazole in the microemulsions of 82% and 95% microemulsion shampoo, the shampoo base as ketoconazole had a percentage of 63% active. The microemulsion systems shown, therefore, effective in solubilizing the active ingredient ketoconazole.