SILVA, R. S. M.; http://lattes.cnpq.br/1053190105268074; SILVA, Rossana Seixas Maia da.
Resumo:
Heparin is a polyanionic polysaccharide that occurs naturally and belongs to the
group of the glycosaminoglycan. It is one of the most powerful anticoagulants of
which mankind has knowledge, taking part in the treatment of several diseases
and hematological alterations. One of the disadvantages of heparin, though, is
the fact that it is severely degraded when taken orally and therefore it is better
introduced via a route other than the mouth. A possible solution to this problem
involves a chitosan/gelatine/heparin blend, provided that both the chitosan and
the gelatine manage to deliver the heparin all the way to the blood flow, not to
mention that the gelatine plays an important role in the process of
homogenizing the chitosan/heparin mixture - with no precipitation. The project's
main goal was to develop and study chitosan/gelatine/heparin membranes. The
membranes with 20mg and 40mg of heparin were prepared by means of
evaporation of the solvent and they were divided in two groups: The first one
was neutralized by the ammonium hydroxide and the second one, by the
sodium hydroxide. Each one of them was submitted to the following
characterization techniques: XRD, FTIR, SEM, DES, Wetting Test, swelling test
and biodegradation tests. In light of the obtained results, it was concluded that
the relation between chitosan, heparin and gelatin was effective. However, a
significant decrease of the heparin in the second group was noticed, and that
was possibly due to the transport of medicine while the membranes were being
cleaned with distilled water.
