TRIGUEIRO, J. A. S.; TRIGUEIRO, Jorge Alberto Silva.
Resumo:
In conventional drug therapy, the drug is administered in a dosage form and
produces a tissue level of the drug is not maintained within the therapeutic
range over an extended period of time. The importance of the release of active
principles stems from the fact that a drug can rarely achieve a specific target in
the body in adequate concentrations to cause the expected therapeutic effect
systems. An ideal drug delivery system should be biocompatible , easily
released , allowing a control of the rate of drug delivery and should not alter the
activity of the drug distribution lately chitosan has gained wide space between
the materials used in the manufacture of these systems meet these needs .
Based on the above this study aimed to develop a system of controls release of
fentanyl parti membrane Chitosan / Fentanyl in the proportions of 5 , 3 and 1 %
drug . Fentanyl was added to chitosan solution and subjected to drying the
solvent to form the membranes , they were characterized to assess the drug /
polymer interactions. It was observed that the addition of fentanyl appropriated
Crystalline membranes , making them less susceptible to biodegradation in
vitro. The final structures had become rough and small grains scattered on its
surface , these grains that were considered contaminants originating from
industrial processing of the drug . There was a decrease in hydrophilicity
directly proportional to the increase of drug concentration and showed no
toxicity. Given the above it can be concluded that the methodology used for the
synthesis of membranes Chitosan / Fentanyl appeared to be effective .
Analyses suggest the presence of fentanyl in the synthesized membranes
causing changes in its degradability , could be a promising material for use in
controlled release drug delivery systems .
