Biomateriais de uso intranasal: caracterização de celulose microcristalina.

Abstract

The rhinosinusopathy is a disease that can be clinically defined as an inflammatory response of the mucous membrane lining anatomical and functional structures of the nasal cavity and paranasal sinuses. Various treatments seek to avoid the onset of the crisis, ie, the preventive treatment we consider to be the ideal treatment and cellulose powder has excelled in the search for treatments of these options, with no adverse effects or side reactions and with positive results. The purpose of this study was to characterize the microcrystalline cellulose (MCC) for intranasal use sold in our country for the treatment of RA. The survey targeted the physicochemical characterization of the MCC was developed in the Laboratory CERTBIO (Laboratory of Biomateriais Development and Evaluation). The chemical composition and crystal structure was confirmed in assays FTIR, XRD and EDS, in which the material can be concluded that it is a cellulose derivative. In analysis by microscopy, MCC presents as a white crystalline powder. One can observe small aspect fibrous particles. The aggregate of microcrystalline cellulose particles have a unique morphology in the form of rods, providing greater compressibility. Through this analysis one can observe the presence of particles ranging from 5 to 100pm. The observation of the material under study and its characterization in favor of the knowledge structure and provides the material becomes susceptible to develop domestic technology that enables us to produce this material with national technical and cost, which would facilitate the access of low-income population to treatment and the prevention of recurrent crises so common in these cases.