Fatores que influenciam a segurança do tratamento farmacológico em pacientes oncológicos pediátricos: uma revisão de literatura.

Abstract

Childood cancer is rare, it may be indicated in absolute numbers, but when it.s displayed in adult incidences a growing profile of incidence rates is presented, it requires a certain competence of the health system for quality care. This assistance cannot be compared to the adult public, since children have physiological differences in different pediatric age groups. Thus, studies of drug use and safety in this public are important in order to promote their rationality, as well as attest to their safe use and effective therapy. Therefore, the study aimed to review clinical practice regarding the safety of pharmacological treatment in pediatric cancer patients. For this, an integrative literature review was carried out through the databases: Scielo, Bireme, PubMed, Portal CAPES and LILACS, using studies published in the last 10 years (2009-2019). We found 89 articles, of which 55 comprised the study. There was a scarcity of studies in the pediatric population, consequently the therapeutic range for this population also decreases, resulting in few therapeutic alternatives. Thus, there is an appeal for the use of medicines outside the terms approved by national and / or international regulatory agencies, providing an opportunity for the clinical pharmacist to act by presenting safety proposals to monitor and suggest strategies for their use in this population.