Avaliação da atividade antifúngica do extrato etanólico de própolis vermelha contra cepas de Candida spp.

Abstract

Candida is a commensal yeast that resides in different parts of our body, but can cause host disease in situations of immune imbalance. Candidiasis is an opportunistic mycosis caused by this yeast, which can be mild, acute or chronic, superficial or deep, and with a very variable clinical spectrum. Thus, the general objective of the study was to evaluate the possible antifungal activity of the red propolis ethanolic extract against Candida strains. The determination of the minimum inhibitory concentration (MIC) was performed by microdilution and triplicate technique, in which the sensitivity of Candida strains to propolis extract concentrations ranging from 15,000 μg/mL to 29,3 μg/mL was verified. . MIC values were determined by visual analysis of growth inhibition. Then triphenyltetrazolium chloride (TTC) was added to determine the minimum fungicidal concentration (CFM). MIC results ranged from 234,4 μg/mL to 937,5 μg/mL. CFM was found to be identical to MIC. From these results in relation to the antifungal potential of propolis extract, the medicinal use of this product for oral cavity infections, especially those produced by the genus Candida, is ratified.