Desenvolvimento de anel intravaginal: quitosana/promestrieno.

Abstract

The present work aimed at the development and characterization of rings biodegradable of chitosan/promestrieno. The rings were produced using the weaving technique with multifilament wires (3 twisted wires). The threads with/without drugs were obtained by extrusion and immersion in coagulant solution, followed by washing and drying of the threads, for subsequent ring weaving. After obtaining the rings, they were characterized by the techniques of Biodegradation, Optical Microscopy (MO), Fourier Transform Infrared Spectroscopy (FTIR), Conductivity, Hydrogen Potential Assessment, Degree of Swelling, Tensile Strength and Thermogravimetry. In Biodegradation, the samples submitted to the acid test showed a greater mass loss as a function of time, in contrast to the samples submitted to biodegradation in the solution of PBS, and PBS with lysozyme. In the analyzes of MO the samples were dense, smooth and without the presence of pores, but after 21 days of biodegradation test. The FTIR showed the characteristic vibrations of the materials and confirmed the incorporation of the drug in the chitosan polymer matrix. In the conductivity and pH results over 21 days of biodegradation assay, distinct steps were observed that revealed the process of matrix degradation and drug release. In the tensile strength test, the use of the weaving technique and the addition of drug in the matrix allowed improvements in the mechanical properties of the rings. In thermogravimetry, the mass loss in the rings with/without drug up to 200 ° C is linked to the evaporation of water in the samples. In general, the rings have potential as estrogen replacement therapy; however, further tests are needed to confirm the use of the device in the controlled release of promestriene.