COSTA, P. C. T.; http://lattes.cnpq.br/3561880881631626; COSTA, Paulo César Trindade da.
Resumo:
The genus Candida represents the main cause of infections of fungal origin. Some species
stand out as disease promoters in humans, such as C. albicans, C. glabrata, C. parapsilosis and
C. tropicalis. For an evaluation of the antifungal activity performed with the determination of
the Minimum Inhibitory Concentration (MIC), the association test with antifungals and
verification of the effect of the test tests on the micromorphology of C. albicans, or the effect
on the growth kinetics of C albicans and the analysis of ergosterol biosynthesis. As minimal
inhibitions of (E) -3- (furan-2-yl) acrylic acid, (E) -3- (furan-2-yl) propyl acrylate,
amphotericin B and fluconazole alone against four species of Candida spp varies from 64 to
512 μg / mL, 64 to 512 μg / mL, 1 to 2 μg / mL and 32 to 256 μg / mL, respectively. The
synergistic effect of (E) -3- (furan-2-yl) acrylic acid was observed when associated with
amphotericin B against C. albicans and C. tropicalis, in relation to (E) -3- (furan-2- il) propyl
acrylate, synergistic effect when associated with fluconazole against C. glabrata, there was no
antagonism between the substances against any of the tested strains. Propyl (E) -3- (furan-2-
yl) acrylic and propyl (E) -3- (furan-2-yl) acrylic promoted morphological changes in C.
albicans, decreasing the amount of resistance structures and virulence, such as the formation
of pseudo-hyphae, blastoconides and claminoconides, guarantee or antifungal potential of
these substances. It was also possible to identify the fungicidal and fungicidal character of (E)
-3- (furan-2-yl) acrylic acid and propyl (E) -3- (furan-2-yl) acrylate, respectively, during the
study of growth kinetics of C. albicans. Finally, (E) -3- (furan-2-yl) acrylic acid increased the
amount of ergosterol in C. albicans and (E) -3- (furan-2-yl) propyl acrylate inhibited the
biosynthesis of ergosterol by yeast. Therefore, this study demonstrated great utility in the
sense of identifying the antifungal activity of both compounds.