Desenvolvimento de biomateriais compósitos Poli-Éter-Éter Cetona (PEEK)/ Hidroxiapatita (HA).

Abstract

The studies aimed at the development of composite biomaterials are increasing, these materials have the advantage of associating the properties of each material used and better meet the requirements for each application. In this research, Poly (ether-ether-ketone) (PEEK), thermoplastic polymer with resistance to high temperatures, chemical resistance and high resistance to wear and Hydroxyapatite (HA), a biocompatible ceramic with main characteristic is the chemical similarity with the mineral phase of the bone. The objective of this work was to develop PEEK / HA composites in different proportions (60, 70 and 80% m / v HA), and to evaluate their physicochemical and biological properties. In this sense, samples of the composites were developed in the different proportions, where they were compacted by the compression molding method, followed by heat treatment in a muffle at approximately 390 ° C, for a period of 30 minutes. The samples were characterized by Vibrational Absorption Spectroscopy in the Infrared Region with Fourier Transform (FTIR), X-ray Diffraction (XRD), Optical Microscopy (OM), Scanning Electron Microscopy (SEM), In Vitro Bioactivity, Cytotoxicity and Adhesion Cell phone. In the physical-chemical characterization of FTIR and XRD it was not possible to identify significant alterations. The FTIR spectra of A1, A2 and A3 do not show formation of new identifiable chemical bonds. In the XRD diffractograms of samples A1, A2 and A3 a profile similar to that of the ceramic phase was observed, with peaks increasing in intensity proportional to the increase of the hydroxyapatite concentration in the composites. In the morphological evaluations of the composites, rough surfaces with signs of roughness and presence of cavities were observed, as well as the deposition of Apatite on the surfaces of composites A1, A2 and A3 after immersion in SBF, demonstrating bioactive capacity, presented higher mean toxicity than 80%, and with it biocompatibility, adhesion and satisfactory cellular development. In this way, it can be concluded that the technique used was efficient for the development of PEEK / HA composites, suggesting the advantageous application of these devices for application as biomaterial.