Avaliação da qualidade de cápsulas de captopril produzidas em farmácias magistrais da cidade de Campina Grande - PB.

Abstract

Systemic Arterial Hypertension and Heart Failure are disorders that compromise the functionality of the System. Captopril is used for symptomatic treatment, and can be presented in the pharmaceutical forms of tablets and capsules. Hard capsules are the pharmaceutical forms most used by magistral pharmacies, a sector that is accessed, thus the present study aimed at evaluating the quality of captopril capsule impressions produced in magistral pharmacies in the city of Campina Grande, Paraíba. The average weight and disintegration tests registered at the Brazilian Pharmacopoeia were performed, and the dosage test using the ultraviolet spectrometry method. The accomplishment of the present work allowed the observation of all the samples that were approved in the tests of average weight and disintegration, however, in relation to the dosage test all were failed, with values of content above what was informed in the label, being thus overdosage . Which leads to the conclusion that although they pass the disintegration and average weight tests, this does not guarantee that the capsules meet the permitted quality requirements, being considered as unsuitable for therapeutic use.