LIMA, M. W. S.; http://lattes.cnpq.br/6797629516072410; LIMA, Maria Wilma Santos de.
Resumen:
Systemic Arterial Hypertension and Heart Failure are disorders that compromise the functionality
of the System. Captopril is used for symptomatic treatment, and can be presented in the
pharmaceutical forms of tablets and capsules. Hard capsules are the pharmaceutical forms most
used by magistral pharmacies, a sector that is accessed, thus the present study aimed at evaluating
the quality of captopril capsule impressions produced in magistral pharmacies in the city of
Campina Grande, Paraíba. The average weight and disintegration tests registered at the Brazilian
Pharmacopoeia were performed, and the dosage test using the ultraviolet spectrometry method.
The accomplishment of the present work allowed the observation of all the samples that were
approved in the tests of average weight and disintegration, however, in relation to the dosage test
all were failed, with values of content above what was informed in the label, being thus
overdosage . Which leads to the conclusion that although they pass the disintegration and average
weight tests, this does not guarantee that the capsules meet the permitted quality requirements,
being considered as unsuitable for therapeutic use.