Obtenção de biomaterial para liberação de fenticonazol, no tratamento da vaginite fúngica.

Abstract

Fungal vaginitis is an infectious and / or inflammatory process of the female genitourinary tract. In the treatment oral and vaginal antifungal agents are used, among them the Fenticonazol. Drug delivery systems have been used as an effective treatment alternative, decreasing the side effects. This work aimed to obtain, evaluate and characterize a biomaterial for intravaginal release of fenticonazole. Were obtained scaffold of Chitosan / phenticonazole / gelatin in the form of ova using the lyophilization method. The samples were neutralized with ammonium hydroxide and characterized by Optical Microscopy (OM), Scanning Electron Microscopy (SEM), X-ray Dispersive Energy Spectroscopy (EDS), Infrared Spectroscopy with Fourier Transform (FTIR), Swelling Degree and Biodegradation. By means of the MO and MEV assay it was observed that the addition of gelatin and the drug altered the morphology of the samples, contributing to densification and consequently to the pore size of the scaffold. X-ray Dispersive Energy Spectroscopy and Fourier Transform Infrared Spectroscopy proved the incorporation of the drug. The degree of swelling was higher in the chitosan / drug sample, which is justified by the network or fibrillar aspect structures. As for the Biodegradation assay, it was observed that the chitosan / drug samples presented lower mass loss when compared to the other samples. In this way it can be concluded that it was possible to obtain a biomaterial using biodegradable polymers with phenticonazole release system.