LEITE, A. G. R.; http://lattes.cnpq.br/9165366829565854; LEITE, Ana Gabriela do Rêgo.
Abstract:
Fructose is best known for innate errors associated with its metabolismo that can have important
clinical consequences. Thus, there are some pathologies associated whith the consumption of
this carbohydrate, onde of which is hereditary fructose intolerance or HFI, a are hereditary
pathology, an autosomal recessive silencing disorder due to the absence or deficiency of the
enzyme aldolase B in tissues. Thus, the induced fructose is unable to be metabolized based on
tissues, causing several potentially fatal symptoms and clinical conditions if they are not treated.
In this sense, the acquisition of more information providing about the processes involved with
the metabolismo of aldolase can contribute to the development of appropriate Technologies to
meet a growing demand in a timely manner in each case, it affections, among intolerances. That
said, the present study aims to: analyze the genetics of fructose intolerance and build specific
primers for genes of the aldolase Family (ALDOB) important in this process. The methodology
applied this work was narrative and with the development of biotechnological and explanatory
potential, as well as a bibliographic review as a tool for understanding the effects of genes and
de environment in the fructose intolerance, more spacifically on the intolerance process, in
addition to to deepen qualitatively the knowledge involving the potentiatities on this issue. The
results showed that the kowledge of nutritionists about certain disorders of nutritional origin is
still scare due to the huge range of possiblie disorders that exist. Thus, it is noted that it is
importante to have a deep clinical look during anamnesis and and na understading of the
diferente factors that are behind certain dirsorders such as intolerances. In addition, it was seen
that there are three genes for aldolase found in humans responsible for the biochemical
pathways of degradation of fructose and mannose borrowed from databases, they are:
(ALDOA), (ALDOB), (ALDOC). Several are as bioenergetic statements influenced by these
genes. These are expressed differently where any change in the metabolism pathway causes
disorders, including fructose intolerance. In conclusion, it was seen that the data obtained in
this work are promising for in vitro studies, in addition to being essential for the construction
of 10 sets of specific primers for this gene, where 6 are potential uses.