SILVA, T. A.; SILVA, Tatiana de Almeida; http://lattes.cnpq.br/0891792122302288; SILVA, Tatiana de Almeida.
Resumo:
Fungi are eukaryotic microorganisms belonging to the Fungi kingdom. Literature cites
several emerging pathogenic fungi, which cause serious infections in humans
humans, being yeasts (eg, Candida and Trichosporon) and
filamentous (eg, Fusarium and Zygomycetes). For this reason, the existence of
several research groups that try to mimic the action of commercial antifungals
making modifications to drugs already used as therapeutic agents, citing the
salicylic acid. Thus, the objective of this work was the synthesis and evaluation of the
fungicidal activity of different salicylic acid derivatives. The acid derivatives
salicylic compounds such as ethyl salicylate, ethyl 2-(ethenyloxy) benzoate and 2-((1-(2-)
ethyl ethoxy-2-oxoethyl) -1H-1,2,3-triazol-4-yl) methoxy) benzoate were synthesized with
yields equal to 79%, 79% and 86% respectively, their structures were
confirmed by infrared and magnetic resonance spectroscopic techniques
nuclear. Ethyl 2- (ethenyloxy) benzoate showed the best antifungal activity
presenting a minimum inhibitory concentration of 512 μg / mL for Candida strains
neoformans ATCC - 66031, A. flavua ATCC - 13013 and Aspergillus flavus LM - 248.
These results encourage a more detailed study of the biological activity of these
compounds, namely, the study of mechanisms of action against strains of C. neoformans
and A. flavus.