LEAL, K. D. B.; http://lattes.cnpq.br/9025523705319885; LEAL, Karla Dalliane Batista.
Abstract:
Acetylsalicylic acid (ASA) is one of the best—selling drugs worldwide for over a century.
Used as analgesic, antipyretic and anti—platelet and its use is scientifically recognized
but still generates differences to some scientists about their indications, benefits and
risks. Quality control plays a fundamental role in all stages of production and marketing
of a drug effective and safe by performing a set of operations in order to verify that the
product complies with the pharmacopoeial specifications. The objective of this study
was to evaluate the physicochemical properties of different tablets (similar and generic)
of acetylsalicylic acid 500mg. The analyzes performed were tests of weight, hardness,
friability, disintegration and quantitication. All tests according to the fifth edition of the
Brazilian Pharmacopoeia (2010). After conducting the tests officers, analyzing the
results, it was observed that the generic was in compliance with all tests, similar to A,
was not in compliance as the disintegration test, 47 minutes and 24 seconds, and the
dosing , 590 mg, similar to B, was not in compliance as the test assay, 581.60 mg and
similar C, was not in line for weight and assay medium, 424.02 mg. Similar
presentations are not within the standards of quality, since that failed in some tests, and
for generic approval at all stages of the study, was a product of good quality, being
within required parameters.
