Membranas gelatinosas mucoadesivas para liberação de anestésico local.

Abstract

Local anesthesia of the oral cavity is a fundamental step in most dental procedures. The noninvasive discipline is applied in local anesthetics in the oral cavity in order to replace the painful injections, enabling the improvement of routine and surgical procedures. However, deep anesthesia and the fixed rhythm of the articular regions of the oral mucosa require penetration of the anesthetic into effective particles. In this work the casting process was used to obtain gelatin membranes with and without bupivacaine for application as an anesthetic mucoadhesive system. Membranes with 2%, 2.5% and 3% of gelatin were obtained with various concentrations of bupivacaine (0.125%, 0.25% and 0.50%). The final solution was poured into petri dishes and the oven evaporated with air circulation at 40 ° C for 24 hours. As membranes were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), In vitro biodegradation / swelling test and moisture assay. Through a dimensional assessment can be greater than a thicker gelatin concentration become like membranes. SEM analysis can be seen that gelatin and non-bupivacaine membranes exhibit surface homogenization, possibly with total drug uptake. The infra-structure spectra can’t be altered when inserting bupivacaine. The assay of biodegradation in vitro shows that membranes are absorbent, swelling and biodegradation, in detecting the weighing and the detection of the same, have been seen membranes have fragmented in fraction of seconds. A hydrophobic membrane is no longer able to do so, it is less than 90 °. Membranes were produced as the research expectations.