OTON, L. B.; http://lattes.cnpq.br/6966438879080691; OTON, Lóide Basílio.
Abstract:
The use of Ginkgo biloba L. (Gb) extracts have been proposed in topical fonnulations for
prevention and treatment of the damages caused by free radicais, due this extract has high
flavonoid content, adding benefit to the compounding product. Such advantages justify tbeir
use by the cosmetic industry, however, there is a need for scientific studies to ensure that
these extracts bave actívíty and tberapeutic efficacy after incorporation into creams. Studies
involving the stability of Ginkgo biloba L. extract in raw material and incorporated in
cosmetic emulsions are rare in literature, being a large part of the studies referring to oral
administration phytotherapy, which limits tbe amount of reference data for comparison. Given
the above, the aim of this research was determining in vitro the antioxidaot activity of Ginkgo
blloba L. in glycolic and dry extract using the free radical scavenging activity on DPPH (2,2-
diphenyl-1-picrylhydrazyl), verify if it has activity when incorporated into the pharmaceutical
fonn cream and with this conduct the study ofpreliminary stability tbrough physical-chemical
tests (pH, spreadability, viscosity, centrifugation and microscopic analysis) to detennine their
bebavior against environmental conditions. The formulations were stable against the physical-
cbenúcaJ stability tests. However, after incorporation in the creams, the extracts of Gb
presented instability against antioxidant efficacy, being observed a greater loss in those
containing Gb glycolic extract. The results point tbe feasibility of using Gb dry extract in
cosmetics of topical use since all the formulations added to this extract, even after thermal
stress, presented antioxidant activity within the pharmacopeia parameters. Thus, the
microencapsulation ofthe extracts is suggested in order to ensure greater bioavailabWty ofthe
active aft.er incorporation in cosmetic producrs, as well as during storage.
