THEOTONIO, J. C. F.; THEOTONIO, Jeisse Clara Felizardo.
Abstract:
Recognition of cancer as a public health problern, corroborates the need for studies on
both its complex pathogenesis, which leads to changes in the genes DNA, and new
clinicai perspectives of treatrnent, especiall)' in chemotherapy, wtth the devclopment of
Target theraptes, based on modulatton of thc tmmune system, agamst aggresstve cancers
and decreased cytotoxtc effects Thus, the study aimed to review the development and
use of Biophannaceuticals, with emphasis on Monoclonal Anttbodtes, in the treatment of
cancer For thts, a research \ .. as carried out in the scientific literature (national and
internattonal), of experimental studies or ltterarure reviev .. s publtshed between the years
2001 to 2016. The rnechanisms of pathogenesis of cancer and the mam phcnotyptc and
metabolic alterations that wcre As phannacologtcal targets, and pointed out the
peculiarities of the immune system that serve as a pillar for the development of
biopharmaceuttcals The structure and methodologies for the production of monoclonal
antibodtes and the mechantsms of acttOn of Rttuximab (Non-Hodking Lyrnphoma) and
Trastuzumab (Breast Cancer) were descnbed, as well as the mam information about its
clinicai use in the Braztlian context of the Unified Health System. And, finally, the
current biostmtlars development scenano ts explained. Of note. therefore. 1s the FDA's
approval of more than two dozen monoclonal antibodies (chtmeric, humantzed and
human) and thetr fragrnents for antineoplasttc trcatment, with an important exccption for
pharmacological targets characteristic of immune cells. dtfferentiation clusters, The
major mechamsms of cell destruction by complement-dependent cytotoxlctt} (CDC)~
Antibody dependent cellular cytotoxictt) (ADCC), Specific cffects on tumor vasculature
and stroma~ And direct mduction of apoptosis, and relevant production methodologies
such as hybndomas, transgenic mice and phage display technology.
