Avaliação físico-química e biológica de fio de polidioxanona revestidos com quitosana.

Abstract

Hysterectomy is one of the most performed gynecological surgeries in developed countries due to various existing conditions, which may also be benign or malignant. However, for the closure of the vaginal vault after the removal of the uterus, the ideal suture thread is needed to accelerate the healing process and promote greater comfort for the patient. There are several suture threads on the market and among them, polydioxanone refers to an absorbable and biocompatible polymeric biomaterial, when barbed it helps surgeons to close the tissue, without the need for us, thus reducing surgical time and losses blood pressures and length of hospital stay. Polydioxanone threads when coated with chitosan can add antibacterial, fungicidal and anti-inflammatory properties, favoring the healing of the vaginal vault after hysterectomy. The present study is justified by the need to research the physical-chemical and biological behavior of chitosan-coated polydioxanone sutures for closing the vaginal vault, aiming at restoring its integrity until its healing. For modification of the surface of the wire was used hydrogen peroxide and later adapted the dip-coating technique with the deposition of chitosan. The wires were characterized before and after surface modification and chitosan coating using Optical Microscopy (OM), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), Infrared Spectroscopy by Transform Fourier (FTIR), Mechanical Tests of Tensile, Degree of Swelling and Biodegradation. Through the technique of MO and SEM it was possible to observe the formation of the coating. With the FTIR technique it was verified that there was an interaction between the wire and the chitosan. The mechanical traction test demonstrated a reduction in tension and an increase in deformation of the modified wires. As for the Swelling test, it was found that chitosan modified this hair profile. In the Biodegradation test, it was observed that the samples in lysozyme presented a greater loss of mass and that the wire kept the same behavior despite the surface modification. Based on the results obtained it can be concluded that the processing condition used proved to be viable regarding the covering of the suture thread with chitosan, making the surface of the same bioactive.