Uso de Rosmarinus officinalis na doença de alzheimer: uma revisão da bibliografia.

Abstract

Alzheimer's disease (AD) is a lenient and silent-onset neurodegenerative disease that affects cognitive and memory-related functions, being said as the main cause of dementia in the elderly, representing more than half of the cases of senility. With the progression of the disease, the characteristic signs and symptoms are showing more and more characteristic and debilitating. The current form of treatment shows an unavailability of cure or a way of stabilizing the disease, with the treatment being aimed at alleviating the signs and clinical symptoms as soon as noticed in order to delay its progression. Although, the conventional first-line pharmacotherapy does not alter the advance or stop the neurodegeneration that is characteristic of the disease. Therefore, the use of plants medicinal as an alternative or therapeutic adjuvant conventional medicine can serve as a tool for a more effective treatment, also gaining prominence as a way of prevention. The objective of the work was to carry out a literature review about the plant medicinal Rosmarinus officinalis, popularly known as Rosemary, being used in treatment of Alzheimer's Disease. The period researched was for works starting from January 1998 to June 2021. A total of 50 articles were found, 11 of which included in this review. Clinical studies, meta-analyses and systematic reviews of studies clinics have shown the efficacy, quality and safety of extracts, essential oils, teas and isolated metabolites for the treatment and prevention of Alzheimer's disease. so it is medicinal plant that deserves attention for its action in disease control, not having presented also signs of adverse effects in the studies performed. However, it is always important ensure its rational use, mainly by the role of the pharmacist in guiding the user.