Alteração da coagulação e covid-19: uma associação entre aspectos epidemiológicos e laboratoriais para o monitoramento da covid-19.

Abstract

COVID-19 is caused by a betacoronavirus, which has spread to several countries, culminating in a pandemic. It is a systemic and inflammatory disease that affects the respiratory tract, as well as causing a series of organic changes, including coagulation disorders, which can be associated with severity and mortality. This study aimed to investigate the epidemiological profile and laboratory parameters of hemostasis in patients with COVID-19, in addition to identifying epidemiological factors that could indicate disease progression and describing changes in hemostasis markers. The research was characterized as a systematic review, using original scientific articles available in the databases (PUBMED, LILACS and SCIELO) using pre-established keywords, whose publication period was from December 2019 to September 2021 With regard to the epidemiological profile, age along with comorbidities were indicators with the greatest association with the progression and mortality of patients with COVID-19 and with coagulation abnormalities, with individuals over 60 years of age having a higher rate mortality rate of 73.3% compared to individuals in the younger age group, and patients with hypertension have a higher prevalence in the population that evolves to death, with 50% compared to 37.9% of patients who survive. Males were the most affected by COVID-19. Coagulation alterations are evident in the laboratory, and D-dimer was the main marker of thrombotic events and mortality. Thus, patients over 60 years of age and who have comorbidities are more likely to progress to a more severe condition of COVID-19. Thus, the association of epidemiological and laboratory aspects of hemostasis are important for monitoring COVID-19, in view of its role in prognosis.