Design de formulação: Curativo a base de hidrogel contendo extratos naturais de Aloe vera e Allium sativum para o tratamento de feridas diabéticas.

Abstract

Injuries to the anatomical structure of the skin of diabetic patients can cause chronic wounds that can lead to physical and psychological impairment, limb amputation and even death. Patients with diabetes mellitus have a delayed wound healing mechanism, the infections in these lesions further increase the chances of limb amputations and death in these individuals. The treatments used for this patients are often expensive, show variable efficacy and are not available to everyone. The need to find safe, accurate and economical wound healing promoters has led medicinal plants and their natural products to be used to treat these comorbidities. Therefore, this work aimed to propose a formulation design containing natural extracts of Aloe vera and Allium sativum incorporated in a hydrogel base for the treatment of infected diabetic wounds, based on the functional characteristics found in these extracts and the advantages that this pharmaceutical form provides for the environment of the injury. This study is a systematic literature review, aimed at extracting information to help define the specificity of the research and provide a theoretical basis for constructing the design of the formulation. The results obtained through the literature review collaborate for the possible application of the formulation, since several studies have obtained significant results when using these components for the treatment of diabetic wounds. The proposed formulation design has several advantages, such as: use of natural extracts with desirable functional effects for wound healing, with simple processes for obtaining, a safe pharmaceutical form that can provide greater effectiveness in healing and the use of low-cost components.