MONTEIRO, C. M.O,; MONTEIRO, Camila Macena de Oliveira.
Abstract:
The 1,2,4-oxadiazoles are heterocyclic compounds of five members, with two nitrogen
and one oxygen atoms, which gained great prominence in the 60s due to their
molecular rearrangements and because they are marketed as drugs acting as cough
suppressants, vasodilators and local anesthetic. In addition, they have a low degree of
aromaticity, being best described as conjugated systems that exhibit a wide range of
biological activities, including antimicrobial, anti-inflammatory, antitumor, anti-
asthmatic, antioxidant. Given the above, the aim of the present work consisted of the
synthesis of 3-(aryl)-5-(heptadecyl)-1,2,4-oxadiazole and evaluation of its toxicity
through the bioassay with Artemia salina Leach. This compound was obtained in
86.48% of yield after 18 minutes of reaction in microwave irradiation followed by
chromatographic column of glass on silica in order to purify this compound, being
further characterized through infrared spectroscopy in which the observed data in the
infrared spectrum confirmed its structure. The evaluation of toxicity against brine
shrimp was performed and with the results obtained it was possible to build a graph
and through it, calculate the estimated value of the lethal concentration to kill 50% of
the brine shrimp. Therefore, the estimated value was equal to 87.84 μg/ml, therefore,
below 100 μg/ml, being classified as a substance of high toxicity, but which can be
used with different biological activities. Thus, it becomes possible to carry out more in-
depth studies that aim to explore the activities that this molecule and derivatives have.
