Síntese e avaliação toxicológica do 1h-1,2,3- triazol 1,4- dissubstítuido.

Abstract

As known as pyrazole, the triazole is a five-membered ring having three nitrogen atoms and two carbon atoms in its structure. From a pharmacological point of view, these compounds have great relevance, since they act as antihypertensive, antitumor, antivirals, antifungals, and analgesics. Furthermore, the 1H-1,2,3-triazole has numerous applications in agriculture and the technological development sector. In this way, the goal for this work consisted of the synthesis of a new triazole compound and evaluation of its toxicity against Artemia salina larvae. As a methodology, the azidation reaction of the n-(4-bromobutyl)phthalimide was performed aiming to obtain n-(4-azidabutyl)phthalimide and then the 1H-1,2,3-triazole 1,4-disubstituted was prepared through Sharpless cycloaddition involving n-(4-azidabutyl)phthalimide and the phenylacetylene. As a result, the n-(4-azidabutyl)phthalimide was obtained with 85%, while the 1H-1,2,3-triazole was obtained in the form of a white-colored solid, with a yield of 83%. Infrared spectroscopic data in the intermediate region (4.000 to 400 cm-1) of the 1H-1,2,3- triazole 1,4-disubstituted corroborates with the compound structure. The toxicological evaluation against the larvae of Artemia salina Leach was inconclusive, due to the low solubility of 1H-1,2,3-triazole 1,4-disubstituted. In short, the method developed for the 1H-1,2,3-triazole 1,4-disubstituted was considered efficient and other biological studies are ongoing.