Desenvolvimento e caracterização de membranas de quitosana/Aloe vera para tratamento de lesões cutâneas.

Abstract

Wound healing consists of dynamic and organized processes that aim to form a tissue which presents function and support similar to that of healthy skin. This process continues to be a great challenge, given its high cost and complexity. Aiming to overcome these barriers, the need has arisen for biomaterials that have lower costs, proven efficacy and safety, and have properties that are as good as those that are already commercially available. The present research aimed to develop and characterize Chitosan and Chitosan/Aloe vera membranes, in different concentrations of the vegetal drug. The groups were divided into Q (pure chitosan), Q025 (chitosan and 0.25% aloe vera), Q050 (chitosan and 0.50% aloe vera) and Q1 (chitosan and 1.0% aloe vera). The characterization of the membranes was done by Fourier Transform Infrared Spectroscopy (FTIR) and Optical Microscopy (OM). The incorporation of the vegetal drug into the membranes was confirmed by the results obtained in MO and FTIR tests. Macroscopically, the membranes showed a homogeneous, smooth, flexible appearance, and a darkening was observed as the concentrations of the plant drug were increased. The chemical study performed by FTIR identified all the characteristic bands of chitosan. With the addition of the vegetal drug, some bands suffered alterations, confirming that chitosan is partially deacetylated and that there was interaction between membrane constituents. From the results obtained it is concluded that the association of chitosan and Aloe vera aiming the production of membranes was successfully achieved, being possible the development of smooth membranes and with interaction between its constituents.