Avaliação histológica da reparação óssea utilizando implantes de silicato de cálcio em tíbia de coelhos.

Abstract

Histological Evaluation of Bone Repair Using Calcium Silicate Implants in Rabbit Tibia. The use of the various existing biomaterials has been a practice frequently studied and used in veterinary orthopedics, due to the necessity of the mechanical adequacy of implants and grafts to the biological environment where it will be implanted. Calcium silicate implants are possible substitutes for bone tissue, as well as any compound that has silicate in its structure, presenting favorable biocompatibility, triggering an osteogenic response through the stimulation and activation of the osteoblastic cells. Recently, a new bioceramic inspired by

Bioeutectic has been proposed. It’s produced by sintering a mixture of α-Ca 3 (PO 4) 2 and α- CaSiO 3 powders with the eutectic dot composition of the system (40% m α-Ca 3 (PO 4) 2

60% m α-CaSiO 3) at 1350 ° C. The purpose of this study was analyze the histological and morphological functionality of the bioceramics which are composed of calcium silicate in the bone repair, compared to the physiological repair without the aid of implants of any other nature, in rabbit’s tibia. Ten healthy male New Zealand rabbits weighing on average 3.5 kg were used. In the proximal and distal metaphyseal regions of both tibias, a circular defect in the bone plane measuring 2.4 mm in diameter was created. In one of the limbs calcium silicate was implanted in both created defects. The obtained results demonstrated a smaller bone formation of the regions where the calcium silicate was implanted, in relation to the response of the physiological repair. It was concluded that the calcium silicate implant was bioactive, osteoconductive, and non-cytotoxic, but delayed bone healing.