LUCENA. W. K. B.; LUCENA, Wanesk Kerly Barbosa.
Résumé:
Effect of Vincristine Sulfate on Intestinal Epithelium and Seminiferous rats. In order to evaluate the influence of the use of vincristine sulfate on rapid multiplication
epithelia in this work are described morphology of the intestinal epithelium (duodenum,
jejunum and ileum) and the seminiferous epithelium of rats treated with 15 days of life and
euthanized in pubertal phase. Mostly the currently available chemotherapeutic agents act in
the destruction of cells in intense multiplication, not exclusive presenting cell selectivity of
tumor cells, causing many deleterious effects in both healthy tissues and in neoplastic cells.
Among the most susceptible tissues are the seminiferous epithelium and intestinal epithelium
since they are in constant cell replication. 10 animals (5 and 5 controls treated with vincristine
sulfate) were used. The drug applications occurred at 15 days of life, and euthanasia at 64
days of life. body weights were measured, intestinal morphometric measurements (villus
height and crypt profundida) and testicular morphometric measurements (tubular overall
diameter, the diameter of the tubular lumen the height of the seminiferous epithelium). The
biometric measurements were made on all animals in the experiment, intestinal morphometric
evaluations were performed in 120 villi and crypts 120 per intestinal segment, and the
morphometric testicular ratings in 200 seminiferous tubules. Thus chemotherapy can cause
serious damage to the intestine and testis, in particular the height of the intestinal villi,
reflecting directly on weight gain. It also promotes the reduction of the testes resulting in
temporary or permanent infertility. However the use of the drug did not significantly
influence cell renewal of intestinal mucosa, and thus the average body weight was also not
changed.
