ALEXANDRE, J. A.; http://lattes.cnpq.br/1075962531917299; ALEXANDRE, João Alves de.
Resumo:
The present work consisted of an experiment with the intention of analyzing the effects of the
ingestion of metabolic residues of Olanzapine found in breast milk on the morphometry and
biometry of the liver of lactating rats. Twenty-four male albino rats were used in the suckling
stage, divided into four groups: control group GC14 and GC21, treated group GT14 and GT21.
The matrices of the control groups were submitted daily to the ingestion of physiological
solution in the same proportion in which the matrices of the treated groups were medicated with
Olanzapine, at the dose of 10mg / kg, from the birth of the pups until the periods established
for the accomplishment of the euthanasia The animals were weighed daily, groups GC14 and
GT14 were euthanized after 14 days of birth and animals of groups GC21 and GT21 after 21
days of birth. The liver was collected, where absolute weight and organ volume were measured.
Histological slides were then made to analyze the hepatocyte diameter of its nuclei and to
investigate the changes resulting from the effects of drug exposure. Data were collected using
Mann-Whitney's non-parametric U-test where a significant difference was detected in all
aspects except the diameter of the hepatocyte nuclei.