Desenvolvimento farmacotécnico e caracterização de gel a base de extrato de Anacardium occidentale L.

Abstract

Among the many plants used in folk medicine, Anacardium occidentale stands out. L., which is a plant belonging to the Anacardiaceae family. Many therapeutic properties are known, such as: antitussive, antisyphilitic, diuretic and healing, in addition to antimicrobial. Several pharmacological actions are attributed to the stem bark, deserving highlight the healing activity. The present study aimed to develop a gel containing glycolic extract of Anacardium occidentale L. with healing activity, through of physical-chemical and microbiological quality control. Two gels were prepared, Gel 1 and Gel 2, composed of Carbopol® 940, propylene glycol, glycerin, EDTA, nipagin, the Anacardiun occidentale L. glycolic extract incorporated into the base gel. The gels were evaluated on days 1, 20, 25, 35. The physical-chemical quality control was carried out through the determination of pH and verification of physical and visual aspects, such as change in staining or precipitation and spreadability test. The formulations showed a pH between 6.0 and 8.0 respectively, normal and homogeneous appearance and characteristic odor, being possible pay attention to the color change of gel 2 after 20 days of study. Gel 2 showed a superior and more homogeneous spreadability. As for the counting test viable microorganisms, carried out for microbiological quality control, was proven that the formulations are within acceptable microbial limits. based on the results of this study, the formulations showed to have physicochemical and acceptable microbiological tests, ruling out the possibility of reformulation.