Avaliação da cicatrização usando um fio de sutura de quitosana com glucosamina em pele de ratos (Rattus novergicus).

Abstract

Chitosan and glucosamine are naturally sourced materials that have several features that allow you not to use it as a suture, so they aim to evaluate the tissue healing in the skin of mice using a glucosamine chitosan thread, thirty-six Wistar rats (Rattus novergicus) were divided into four groups according to the material used for suturing the skin, being group Q (chemotherapy thread), group QG (glucosamine-associated chemotherapy thread), group C ( commercial catgut® wire) and SS group (without suture). All animals are part of two groups, with 2 longitudinal incisions of 2 cm being made in the dorsal region, one incision in the right side represented in one group and in the other left side. different time periods (7, 14 and 28 days) after suture, then healing tissues were removed for histological evaluation, no macroscopic examination found edema in animals in groups C and SS, and a lower inflammatory and faster healing in groups Q and QG In the histological evaluation the intensity of the inflammatory infiltrate was higher in group C (p = 0.042), and the granulation tissue reaction (p = 0.015) and the process repair (p = 0.003) were the first in group C with significant difference in the QG and SS groups. The results indicate that the chitosan thread associated with glucosamine, as an alternative for use in surgical practice.