SILVA, R. C. M. O.; http://lattes.cnpq.br/1109841685667341; SILVA, Rebeca Cícera Mendes de Oliveira.
Abstract:
The study and manufacture of therapeutic innovations of plant origin include several
steps. In the course of preclinical studies, experiments are performed to determine
the safety of the use of that compound that has been isolated from the plant in
humans, then tests are performed to evaluate the toxicity of the product, as well as
whether it has the possibility cause mutagenic and carcinogenic effects. The Psidium
guinean Sw, which is popularly called "true arachis", "araçá do campo" and "wild
guava" belongs to the family Myrtaceae and has already presented several biological
effects published in the literature, however, few toxicological studies are conducted
with their extracts. Based on this, the objective of this study was to analyze the
genotoxic potential of the extracts of the plant Psidium guineense SW, against cells
of the oral cavity. Based on the results, it can be seen that no extract tested showed
high micronucleus, binuclation, caryolysis and karyorrexe levels in the oral mucosa
cells in comparison to the positive control. Therefore, it is concluded that Psidium
guineense SW extracts present a low genotoxic potential.