Biocompatibilidade dos adesivos cirúrgicos etil-cianoacrilato e n-butil-2 cianoacrilato+octil-2- cianoacrilato.

Abstract

An atraumatic treatment for surgical wounds that restores tissue to its condition of normality was what led over the years to the emergence of different materials such as absorbable, non-absorbable, monofilament suture threads, multifilaments, surgical cements and cyanoacrylate-based adhesives, the latter has been extensively evaluated both in medicine and dentistry with results promising. This study focused on histologically analyzing the biocompatibility of cyanoacrylate-based adhesives: ethyl-cyanoacrylate (Tek Bond) and n-butyl-2 + octyl-2-cyanoacrylate (GlubranTiss) in subcutaneous tissue of rats. Thirty-six male Wistar rats were used, divided into 3 groups (n=12), as follows:

Group C (control, PVA Sponge), Group EC (Ethyl-cyanoacrylate) and Group NO (N- butyl+2-Octyl cyanoacrylate). The animals were sacrificed after 7, 15 and 30 days and the

tissues analyzed under optical microscopy for infiltration events inflammatory, edema, necrosis, granulation tissue, giant cells, fibroblasts

youth and collagen fibers. The results were analyzed by the Kruskal- Wallis and Dunn (P<0.05). Intense inflammatory infiltrate was demonstrated in the NO groups

and EC, with a significant difference between the Control Group and the NO and EC Groups in time of 7 (P=0.012) and 30 days (P=0.008), and between the Control and NO Groups in the time of 15 days (P=0.013). Giant cells were more expressive in the NO Group throughout of the experiment, there was a statistical difference between the Control and NO Groups in times of 15 (P=0.006) and 30 days (P=0.028). The amount of collagen fibers increased throughout the experiment, there was a statistically significant difference only between the Control and EC Groups at 30 days (P=0.033). you can conclude that the adhesive N-butyl + 2-Octyl cyanoacrylate had the greatest influence on the

number of multinucleated giant cells, and Ethyl-cyanoacrylate demonstrated lower amount of collagen fibers in 30 days.