Utilização de quitosana, gelatina, hidroxiopatita 𝜷�-trifosfato de cálcio, na regeneração óssea de coelhos.

Abstract

The aim of this research was to evaluate the process of bone regeneration in rabbits by the use biopolymers and calcium phosphate in two separate experiments. Adult rabbits of both sexes, of New Zealand race. Animals were randomly divided according to experimental moments. Were made perforations both tibias and were introduced implants according to each experiment and compared with the control group. Computed tomography evaluation was conducted to compare the healing process through the radiodensity of bone lesions in bone tissue. The histological comparative descriptive, it was found that all treatments, at all times, stimulated reactions more pronounced and accelerated bone repair. In the morphometric analysis, all treatments induced bone formation significantly higher than the control group (p<0.05) and in the evaluation of scanning electron microscopy, the treated group showed greater bone neoformation than the control group. It is conclude that biomateriais used in the experiments of this thesis induce bone formation greater than the control group.