Uso da xilazina, medetomidina ou dexmedetomidina na anestesia dissociativa em coelhos.

Abstract

The objective of this study was to compare the anesthetic effects promoted by ketamine associated/mixed with three different α2-agonists in rabbits. Were used 6 healthy animals, (SRD) mixed breed, weighing 2.42+0.36 kg, submerged to treatments called GCX, and GCD GCM. The fixed-dose ketamine (15 mg/kg) combined with xylazine (10 mg/kg) was administered intramuscularly in the GCX, the dexmedetomidine (0.05 mg/kg) in GCD and medetomidine (0.25 mg/kg) in the GCM. Were evaluated the HR, RR, CT, SPO2, MAP, glucose, electrocardiography, latency, able anesthetic and recovery period. The records of the variables were initiated before drug administration (basal) and every 5 minutes after taking them for 50 minutes. Data were subjected to ANOVA followed by the Tukey test (P<0.05), for the clinical variables, and the "t" test of Student (P<0.05) for the other variables. More stable HR and MAP, respectively were obtained in the GCD and the GCM. There was a reduction of the average of RR and hyperglycemia in all groups. In the PR GCX had high averages from M5. We conclude that the effects were similar in both groups and without significant changes in the physiology of rabbits. It is worth mentioning a better cardiovascular stability associated with the use of dexmedetomidine.