VASCONCELOS, J. S.; http://lattes.cnpq.br/4010472578299660; VASCONCELOS, Jackson Suelio de.
Resumen:
Are described in three papers tumor and non-tumor skin diseases of dogs in João Pessoa
and metropolitan region. This thesis is composed of three articles. In the first chapter,
submitted to the journal Veterinary Research Brazilian, described the frequency of skin
diseases that affect dogs in the metropolitan region of João Pessoa, Paraíba, Brazil. For the
execution of the work were performed clinical exams, dermatological examinations and
complementary tests. The most frequently observed lesions were characterized by areas of
alopecia, hipotricóicas, spotted, erosive and ulcerated, placodes, erythematous, as
comedones, collarettes, seborrhea. The parasitic skin diseases were the most frequent
(35.35%, 76/215), followed by bacterial dermatopathies (24,19%, 52/215), allergic
dermatopathies (20,00%, 43/215), fungal dermatopathies, 21%, 37/215), dermatopathies
for various causes (2.32%, 5/215) and autoimmune skin diseases (0.93%, 2/215). The
second chapter accepted in the journal Veterinary Research Brazilian, describes the clinical
and histopathological features of allergic dermatitis in dogs diagnosed the metropolitan
region of João Pessoa, Paraíba. Of 90 dogs with cutaneous lesions, 24 presented alterations
compatible with allergic dermatitis. Atopic dermatitis (AD) was the most common,
followed by food hypersensitivity dermatitis, allergic contact dermatitis (DAC), flea bite
allergic dermatitis (DAPP), drug hypersensitivity (pharmacodermia). The third chapter
submitted to Brazilian magazine Archive of Veterinary Medicine and Animal Science,
describes the characterization of pathological and immunohistochemical aspects of tumors
of the skin glands in dogs. Morphological characterization followed the updated
classification of the World Health Organization as to characterize immunohistochemistry
was used primary monoclonal anti cytokeratin 14 (CK14), vimentin, p63, calponin, EGFR
and Ki-67. Of the tumors characterized, 40.74% were hepatoid (11/27), 29.63% sebaceous
(8/27), 25.92% apocrine (7/27) and 3,70% Meibomium (1/27). The CK14, p63, vimentin
and EGFR antibodies were immunoexpressed in basal cells, sebaceous differentiation of
hepatoid and Meibomian tumors and myoepithelial cells, whereas vimentin and EGFR did
not demonstrate immunostaining for sebaceous tumors. Calponin was a good marker for
myoepithelial cells. The Ki-67 index was more pronounced in malignant tumors compared
to benign tumors. The LPA and LPV, provide an important service in the diagnosis of
tumor and non-tumoral dermatopathies. In dogs in the state of Paraíba. The correct
diagnosis of dermatopathies in dogs contributed to knowledge, control and treatment, since
this group of diseases correspond to more than 25% of the casuistry in the dogs' medical
clinic. The correct dermamatological examination associated with compliant exams such as
skin parasitology, trichrome, cytopathology, histopathology and immunohistochemistry
were important tools for the diagnosis of dermatopathies. The LHAP of UTAD in Vila
Real, Portugal, provides important services in the learning of the immunohistochemical
technique, aiding in the diagnosis of tumors of cutaneous glands.