Dermatopatias diagnosticadas em cães.

Abstract

Are described in three papers tumor and non-tumor skin diseases of dogs in João Pessoa and metropolitan region. This thesis is composed of three articles. In the first chapter, submitted to the journal Veterinary Research Brazilian, described the frequency of skin diseases that affect dogs in the metropolitan region of João Pessoa, Paraíba, Brazil. For the execution of the work were performed clinical exams, dermatological examinations and complementary tests. The most frequently observed lesions were characterized by areas of alopecia, hipotricóicas, spotted, erosive and ulcerated, placodes, erythematous, as comedones, collarettes, seborrhea. The parasitic skin diseases were the most frequent (35.35%, 76/215), followed by bacterial dermatopathies (24,19%, 52/215), allergic dermatopathies (20,00%, 43/215), fungal dermatopathies, 21%, 37/215), dermatopathies for various causes (2.32%, 5/215) and autoimmune skin diseases (0.93%, 2/215). The second chapter accepted in the journal Veterinary Research Brazilian, describes the clinical and histopathological features of allergic dermatitis in dogs diagnosed the metropolitan region of João Pessoa, Paraíba. Of 90 dogs with cutaneous lesions, 24 presented alterations compatible with allergic dermatitis. Atopic dermatitis (AD) was the most common, followed by food hypersensitivity dermatitis, allergic contact dermatitis (DAC), flea bite allergic dermatitis (DAPP), drug hypersensitivity (pharmacodermia). The third chapter submitted to Brazilian magazine Archive of Veterinary Medicine and Animal Science, describes the characterization of pathological and immunohistochemical aspects of tumors of the skin glands in dogs. Morphological characterization followed the updated classification of the World Health Organization as to characterize immunohistochemistry was used primary monoclonal anti cytokeratin 14 (CK14), vimentin, p63, calponin, EGFR and Ki-67. Of the tumors characterized, 40.74% were hepatoid (11/27), 29.63% sebaceous (8/27), 25.92% apocrine (7/27) and 3,70% Meibomium (1/27). The CK14, p63, vimentin and EGFR antibodies were immunoexpressed in basal cells, sebaceous differentiation of hepatoid and Meibomian tumors and myoepithelial cells, whereas vimentin and EGFR did not demonstrate immunostaining for sebaceous tumors. Calponin was a good marker for myoepithelial cells. The Ki-67 index was more pronounced in malignant tumors compared to benign tumors. The LPA and LPV, provide an important service in the diagnosis of tumor and non-tumoral dermatopathies. In dogs in the state of Paraíba. The correct diagnosis of dermatopathies in dogs contributed to knowledge, control and treatment, since this group of diseases correspond to more than 25% of the casuistry in the dogs' medical clinic. The correct dermamatological examination associated with compliant exams such as skin parasitology, trichrome, cytopathology, histopathology and immunohistochemistry were important tools for the diagnosis of dermatopathies. The LHAP of UTAD in Vila Real, Portugal, provides important services in the learning of the immunohistochemical technique, aiding in the diagnosis of tumors of cutaneous glands.