Agonistas a2 adrenérgicos pela via espinhal em animais e avaliação da dexmedetomidina ou xilazina epidural em coelhos.

Abstract

The α2 adrenergic agonists are drugs very used for animal sedation, however the continuous looking for alternatives in the pains treatment and prevention has made your use by spinal route a good choice. Since the 1980 decade very papers has demonstrated the advantages of the practice, but there is many controversy around the analgesic doses that promote little systemic effects as well as about the neurotoxicity. The aim of this dissertation was congregate dates about the epidural and intrathecal use of α2 adrenergic agonists drugs in animals in a review paper and to assess the epidural use of dexmedetomidine or xylazine, associated to lidocaine, in rabbits, in the anesthesiologic and histopathological aspects. There a tenuous line between the obtention of segmentary analgesia and sedation and other systemic effects, what require caution of the anesthetist while to choice the technique in cases that sedation and decubit are undesired. However, how in the spinal route the doses are smallest than the systemic routes this technique can to be considered in patient with the systemic use this drug will be contraindicated. The epidural administration of xylazine (3mg/kg) and dexmedetomidine (10μg/kg) associated with lidocaine induced bradypnea in all rabbits, but the SpO2 was in the limits in ones with received xylazine. The drugs tripled the anesthetic time and along in 63% the time of walk return promoted by lidocaine. The segmentary analgesia has promoted by α2 agonists assessed was equipotent, but the xylazine, despite satisfactory contention, caused cardiovascular impairment that limit its use at the assessed doses.