Efeitos da dexmedetomidina associada à cetamina em coelhos.

Abstract

The evaluation of new anesthetic techniques is important to know the possible side effects that drugs can cause. The dissociative anesthesia is used routinely in veterinary medicine in combination with α-2 adrenergic agonists or benzodiazepines. This dissertation was divided into two original chapters based on the evaluation of the association of dexmedetomidine and ketamine. In the first chapter was made a comparative assessment of cardiorespiratory effects of these two drugs administered intramuscularly or by continuous infusion in rabbits. In the second chapter was evaluated the influence of anesthesia with the combination of dexmedetomidine and ketamine by continuous infusion in rabbits submitted to controlled hypovolemia. In both experiments were evaluated clinical and electrocardiographic parameters, the second chapter was additionally evaluated the blood gas variables. In the two sections it was concluded that the combination of ketamine and dexmedetomidine provided minimal physiological changes in animals.