Comparação de variáveis clínicas e laboratoriais de cadelas com piometra aberta e fechada e determinação de biomarcadores renais e do índice de resistividade renal em cadelas com piometra aberta.

Abstract

The objective of this study was to evaluate clinical, laboratory and renal resistivity index in bitches with pyometra. In the first chapter, a retrospective comparative study of 30 bitches with pyometra was performed, which were divided into two groups: GPA (Piometra open group) composed of 17 bitches and GPF (closed Piometra Group) composed of 13, attended at the Veterinary Hospital / UFCG / Campus Ducks. Variables related to age, race, anamnesis data, physical examination and laboratory tests were analyzed. It was found that the mean age of bitches was 6.2 ± 3.0 years for GPA and 7.8 ± 4.4 years for GPF, with undefined animals being the most affected in both. Among the groups, there was no statistically significant difference for the variables: age, anorexia, apathy, degree of dehydration, abdominal distension, polyuria, polydipsia, vomiting, sepsis, urea, creatinine, ALT and AF, as well as hematocrit, except for the platelet variable, where a statistically significant difference was observed (p <0.05). It was found that bitches with open pyometra were clinically and laboratorially as severe as those with closed pyometra, emphasizing the importance of intensive monitoring and treatment for these patients, both in the pre- and postoperative periods. In the second chapter, renal injury markers such as urea, creatinine, urinary gammaglutamyltransferase (GGT), urinary protein / creatinine ratio and microalbuminuria were analyzed, as well as the renal resistivity index in six bitches with open pyometra, Veterinary Hospital / UFCG / Campus Ducks. Urea and creatinine levels were elevated in 16.6% (1/6) of the bitches; the protein: urinary creatinine ratio was increased in 66.6% (4/6) of bitches, the range value -glutamyltransferase (GGT) was increased in 50% (3/6) of the bitches, 16.6% (1/6) of the six bitches presented microalbuminuria and the renal resistivity index was increased in the right and left kidney of 66 , 6% (4/6) of bitches. There was no statistical difference between the values of the right and left kidney. It should be emphasized that these tests should be performed on bitches with open pyometra, in order to diagnose renal insults early. In general, it is concluded that the open pyometra diagnosed late, has the potential to cause changes as severe as the closed one, and should be given greater attention. And acute renal lesions can and should be identified early in patients affected by this disease, improving their prognosis and survival.