Fio de quitosana: propriedades mecânicas e efeitos na cicatrização tecidual em coelhos.

Abstract

This thesis consists of two chapters, the first chapter aimed to evaluate the mechanical and dimensional properties of chitosan-based suture, comparing them with those recommended by the NBR 13904/2003. Used was a universal testing machine and a digital micrometer. The mechanical and dimensional parameters analyzed were the resistance and tensile strength and diameter, respectively. The average diameter of the chitosan showed variation and yarn tensile strength was observed slightly below the recommended standard, with rapid deformation. The chitosan yarn in the form in which it was produced, presented dimensional variability and low tensile strength, there is a need for improvements in the method of manufacturing the same. In the second chapter aimed to evaluate the healing process of rectus abdominis muscle in rabbits submitted to laparotomy and laparorrhaphy using the wire chitosan-based suture, comparing it to the wire chrome and polyglactine catgut 910. 24 were used adult rabbits, divided into four groups: chitosan and catgut 15 days (QC-15dias), chitosan and catgut 30 days (QC-30 days), chitosan and polyglactin 910 15 days (QP-15 days) and chitosan and polyglactin 910 30 days (QP-30 days), each group consisting of six rabbits in which there were two bilateriais incisions paramammary by laparotomy technique subsequently performed laparotomy with chitosan wire on one side and the other with the chromic catgut or polyglactin 910. the wire production methodology influenced the toxicity of it that triggered a marked inflammatory response impairing the healing process, with the need for further studies and improvements in the production method of chitosan wire. It was concluded that the form of production of chitosan wire interfered with his biomechanics, dimensional value and biological response, presenting with low tensile strength, variability in size and impairing the healing process in rabbits.