BORGES, I. L.; http://lattes.cnpq.br/8281892839244064; BORGES, Ismael Lira.
Abstract:
A retrospective study of the necropsy cases of dogs diagnosed with lymphomas was carried out
in the Laboratory of Animal Pathology of the Veterinary Hospital Prof. Dr. Ivon Macêdo
Tabosa of the Federal University of Campina Grande, Patos Campus, Paraíba over the period
from January 1986 to December 2018. The study resulted in three chapters of the dissertation.
The first one entitled "Clinical and anatomopathological characterization of lymphomas in
dogs: 51 cases" adressed the frequency of dogs with lymphomas, their age, sex and breed
profiles, clinical signs, macroscopic and microscopic findings. Of 2600 necropsies performed
in dogs, 304 were diagnosed with neoplastic disorders and of these, 51 with lymphoma. Males
were more affected than females and average age of dogs was 7.8 years old. The mixed breed,
Rottweilers and Poodles were the most affect breeds. The main clinical signs were: anorexia,
lymphadenomegaly, pale mucosae, jaundice, apathy, prostration, skin lesions and vomiting.
Five animals had isolated lymphomas in the liver (2 cases), heart (2 cases) and kidney (1 case).
Already 46 had multicentric lymphomas affecting, mainly liver, lymph node, spleen, kidneys,
lung, skin and heart. Different macroscopic and microscopic lesions were visualized. The
second chapter entitled "Clinical, anatomopathological and immunohistochemical features of
lymphomas envolving the central nervous system in dogs: 7 cases" aimed to describe seven
sporadic cases of secondary lymphomas of the central nervous system in dogs pointing the
characteristics of the study population, the clinical signs, the macroscopic, histopathological
and immunohistochemical findings. Four animals were males and three females and the mean
age of the affected dogs was 7.4 years old. Three animals were mixed breed, two Rottweilers,
one Dachshund and one German Shepherd. Clinical signs consisted of seizures, ataxia, local
pain, opisthoton, bilateral blindness, and Schiff-Scherrington syndrome. Mainly, macroscopic
lesions occurred in the meninges and in the encephalon. Microscopically the main distribution
pattern was intravascular and four cases were classified as nonspecific peripheral T-cell
lymphomas and three as intravascular T-cell lymphomas. The third chapter titled
"Hepatocytotropic T-cell lymphoma in a dog: case report" included a rare case of
hepatocytotrophic lymphoma in a cross-breed dog, 11-year-old male, highlighting its clinical,
anatomopathological and immunohistochemical findings. The dog showed inappetence,
anorexia, vomiting, diarrhea, jaundice, hepatomegaly and alterations in hepatic and renal serum
biochemistry. At the necropsy we observed a diffusely yellowish and enlarged liver with
bulging edges and accentuation of the lobular pattern. Microscopically, diffuse infiltration of
neoplastic lymphoid cells was observed in the sinusoid lumen and dissecting the hepatocyte
strands individually or in small clusters. Similar infiltrate was observed in the kidneys. The
immunohistochemical profile revealed CD3 / CD20 co-expression with a predominance of
CD3-positive neoplastic cells being classified as hepatocytotropic T-cell lymphoma. With this
work it was possible to determine the frequency of dogs with lymphomas diagnosed at
necropsies at the Laboratory of Animal Pathology of the University Federal de Campina Grande
found that it is a frequent neoplasm in the routine and one of the main causes of death in these
animals. They affected the various systems including the nervous system and showed a great
variety of clinical signs and macroscopic and microscopic lesions.