Efeito da lidocaína sobre a indução anestésica com propofol ou alfaxalona em felinos.

Abstract

In order to evaluate the effect of the intramuscular administration of lidocaine on the induction dose of propofol and alfaxalone in felines, this dissertation was divided into two chapters: the first to evaluate the effect of the intramuscular administration of lidocaine on propofol induction dose and some physiological parameters such as: heart rate ( HR), electrocardiogram, respiratory hate ( RR), systolic arterial pressure ( SAP), oxyhemoglobin saturation(SpO2) and body temperature ( BT), total propofol dose, skillful anesthetic period and anesthetic recovery time in felines and the second, o evaluate the effect of the intramuscular administration of lidocaine on the induction dose of alfaxalone as well as the skillful period and anesthetic recovery time plus some cardiorespiratory parameters and body temperature in domestic cats. In the first article ten female cats were used in two groups, each animal being his own control where they received 0,9% NaCl or 2% lidocaíne (7mgkg) both intramuscularly. The changes observed in all evaluations of the measured physiological parameters of the GP and LPG remained within the normal range for the feline species as well as the electrocardiographic parameters. It was concluded that lidocaine does not potentiate the hypnotic effect of the propofol and causes minimal changes in physiological parameters, but there was an increase in the anesthetic recovery time of the LPG group which was 39,50 ± 9,25 minutes compared to the GP 26,00 ± 9,25 minutes. In the second study seven cats were used in two groups, each animal being its own control, which received 0.9% NaCl solution or lidocaine ( 7 mg kg) intramuscularly (IM). The minimal variations observed in the evaluated clinical parameters of GA and GLA remained within normal range for felines, as well as the electrocardiographic parameters evaluated and that there were no significant changes regarding the duration and time of anesthetic recovery in both experimental groups. It is concluded that lidocaine, in the administration route used, does not potentiate the hypnotic effect of the alfaxalone and does not alter the evaluated parameters or anesthetic recovery. The two chapters that make up this dissertation allow us to conclude that intramuscularly administered lidocaine did not decrease the total propofol dose or the total alfaxalone dose causing minimal changes in the parameters evaluated in the feline species, however increases the anesthetic recovery time of the GLP whereas in the experiment with the alfaxalone anesthetic, it did not potentiate its hypnotic effect, promoted minimal changes in feline physiological parameters and did not interfere with the anesthetic recovery time.