Avaliação clínica e histopatológica da cicatrização do nervo ciático de coelhos (Oryctolagus cuniculus) submetidos à neurotmese e neurorrafia periférica com duas técnicas, associado ao uso de implantes de quitosana.

Abstract

Traumatic processes retain great importance in veterinary medicine, with the largest number of cases being attended at the surgical clinic of small animals; and within these processes the involvement of injuries to the nervous system is a great concern due to its connective integrity with all other systems. Peripheral nerve damage can cause irreparable damage and severe impairment of limb function when not properly corrected, mainly because of its limited repair capacity. Nerve repair is a challenge in medicine, and some areas of biology and engineering have been working together, such as materials engineering, to develop products that can promote difficult tissue repair. The first chapter of the present study aimed to evaluate surgical techniques used in the repair the peripheral nerve, in the second chapter the association of chitosan based implant with the best result technique was compared. Ten rabbits (Oryctolagus cuniculus of the Leporidae family, New Zealand line), healthy, aged approximately twelve months and weighing between 2.0 kg and 3.5 kg, submitted to the total sciatic nerve section were studied. Clinicalneurological and histopathological evaluations were performed to evaluate functional limb return and progression of nerve healing.