COSTA, E. I. S.; http://lattes.cnpq.br/9292843639986954; COSTA, Edla Iris de Sousa.
Abstract:
The present study consists of two chapters. In the first chapter, the objective was to evaluate
the diffusion area of ioversol 320 mg I/mL, when administered in two different doses, via the
lumbosacral epidural route in bitches, also analyzing the possible changes in the physiological
parameters caused by the administration. For this, 10 bitches were used, randomly allocated
into two groups, in which the contrast was administered at the doses of 0.05 mL/cm and 0.1
mL/cm of the spine. In addition to contrast migration, the following parameters were
evaluated: heart rate, electrocardiography, systolic blood pressure, respiratory rate, peripheral
oxyhemoglobin saturation, body temperature and skin surface temperature. Such parameters
were evaluated before the anesthetic procedure and contrast administration and every 10
minutes after, for one hour. The use of ioversol at doses of 0.05 mL/cm and 0.1 mL/cm
provided diffusion through the epidural space that reached the T10 and T5 vertebrae as
medians, respectively, without causing adverse effects in the bitches. The second chapter
deals with a systematic review on the administration of opioids through the epidural route,
carried out in the Pubmed and Science Direct databases, in order to select the most relevant
articles on the proposed topic. Fifty articles were found, of which 15 were selected after
applying the inclusion criteria, which contained relevant information. Several opioids have
already been administered via the epidural route, showing efficacy in controlling
postoperative pain, as the duration of the epidural route is prolonged and its adverse effects
are reduced.