Hepatite infecciosa canina diagnosticada no Laboratório de Patologia Animal do Hospital Veterinário da UFCG, Patos, Paraíba.

Abstract

Twelve cases of Infectious Canine Hepatitis (ICH) were diagnosed based on its characteristic pathologic findings of the disease . All cases showed necrosis and hemorrhage with intranuclear inclusions in hepatocytes. We evaluated the epidemiological, clinical and pathological features of a total of 986 sheets necropsy reports, from January 2003 to June 2013, showing a total of 1.21 % of the occurrence of the disease in the region . 50% of the affected animals were adults (6/12) and 50% were younger (6/12). In 8.33 % of cases the animals showed immunization. The clinical course ranged from acute (5/12) the hyperacute (4/12) lasting up to 7 days. Clinical signs observed were lethargy (5/12), seizures (4/12), mucosal petechiae ocular, oral and skin (4/12) , decreased appetite (2/12) , diarrhea (2/12) , vomiting (1/12) and submandibular edema (1/12). Clinical suspicions were poisoning (3/12), ehrlichiosis (4/12), parvovirus (2/12), uniformed (2/12) and endoparasitose ( worms ) (1/12). The Necropsy findings consisted of liver ranging from pale orange to reddish areas with multiple randomly distributed throughout the parenchyma (9/12) and accentuation of the lobular pattern (7/12). Hemorrhages were observed in the intestine (10/12), stomach (10/12), thymus (2/12), spleen (4/12), lung (5/12), heart (6/12), brain (3/12), kidney (12/9), bladder (3/12) , oral mucosal , ocular, subcutaneous and (7/12). Jaundice (2/12) and submandibular edema (2/12) and enlarged lymph nodes were observed in four of the twelve cases. In all cases, the liver necrosis region centrilobular hepatocytes sometimes extending to the middlezone (8/12) associated with bleeding (10/12) and infiltrates. Intranuclear inclusions were seen in normal hepatocytes necrosis and process individual as well as in endothelial cells of blood vessels. The inclusions are characterized by basophilic some met the entire core (1/12), but most had a clear halo boundary between the insert and the nuclear membrane. Inclusions were also found in the reticuloendothelial cells of the spleen cells in glomeruli of the kidney and brain endothelial cells. Vaccination correct and careful disinfection and hygiene of the places where animals live are not important factors for disease occurrence. The disease occurred in animals of different age groups, but always related to the failure of vaccination. All cases of dogs that died in the small animal clinic or were referred for autopsy examination there was no clinical suspicion of the disease. The dogs with ICH may exhibit signs secondary to neurological and vascular lesions being mistaken for primary diseases of the central nervous system. In some cases where there epidemiology and clinical manifestations are mainly suggestive of ehrlichiosis, intoxication (poisoning) or parvovirus HIC must include in the differential diagnosis.