Análise tomográfica da utilização de quitosana e de β-trifosfato cálcio isolado e associado na regeneração óssea de coelhos.

Abstract

The objective of this study was to evaluate the use of chitosan and P-triphosphate calcium in bone healing by means of clinical evaluation and computed tomography. Therefore, we used 12 adult rabbits, weighing 3 kg on average. In each animal were made four tibial osteotomies, one proximal tibia and distal metaphysis of each other tibia. The metaphysis of the left tibia osteotomy was performed without introducing any biomateiral (control group) was placed in the osteotomy distal implant chitosan. In proximal metaphyseal osteotomy of the right tibia was introduced p-triphosphate and calcium in the distal composite chitosan / P-calcium triphosphate. The animals were evaluated clinically for a period of 10 days. Meanwhile there was no wound dehiscence and ambulate normally. After this period the animals were euthanized and the tibias removed for tomographic analysis. In the tomographic evaluation there was a statistically significant difference (p> 0.05) between groups for time between times or by group, however, the tomographic images of the implants showed greater radiopacity, which implies a greater amount of tissue newly formed in relation to the control group.