CAMPOS, E. M.; http://lattes.cnpq.br/9818453143725127; CAMPOS, Édipo Moreira.
Resumo:
This thesis describes three scientific articles that address central nervous system diseases
in goats and sheep in Northeastern Brazil. The first chapter brings together and describes
the cases of CNS malformations in goats and sheep during the period 2000 to 2019 of
diagnosis at Laboratorio de Patologia Animal da Universidade Federal de Campina
Grande. During the study period, 1012 goats and 834 sheep were received for necropsy,
of which, eight were diagnosed as CNS malformations, three cases of lissencephaly with
cerebellar hypoplasia in goats, two cases of anencephaly in goats, one case of acephaly
in sheep, one case of microcephaly in sheep and one case of diplomyelia with
diastematemyly in goats . For most animals, the disease had an acute and very lethal
clinical course. The second chapter describes two cases of lissencephalypachygyria
and
cerebellar hypoplasia in goats from the same herd, offspring of the same sire and different
breeders. The animals were young and fed from a bottle. On physical examination, they
presented incoordination and inability to stand, permanent sternal decubitus, ataxia,
absence of threat reflex, intention tremors and nystagmus. With evolution of clinical
signs, the animals died and were necropsied. At necropsy, the brain of both animals did
not show gyrus or sulci and the cerebellum was reduced in size. Histologically,
throughout the cerebral cortex, the gray matter was thicker and the white matter thinner
than normal. Neurons were randomly distributed in the gray matter. In the cerebellum,
the layers were disorganized, with heterotopic location of the cells. All injuries were
common to both cases, varying only in intensity. The third chapter describes two cases of
systemic eimeriosis in goats, one of them with cerebral involvement. The two goats were
female, one month old of the Saanen breed. The animals had diarrhea progressing to
neurological signs. On physical examination of one of the animals, lethargy, reluctance
to movement, bruxism, ataxia, walking in a circle, decreased visual acuity, anorexia,
abdominal distension and respiratory difficulties were observed. The parasitological
examination showed marked emeirid oocysts. With the clinical evolution, the animal died
and was necropsied. Macroscopically, the lesions were restricted to the small intestine,
which had a lot of mucus and whitish multifocal nodules and slightly elevated in the
mucosa. Microscopically, mononuclear leptomeningitis associated with intralesional
Eimeria oocysts, severe chronic enteritis and the presence of marked oocystic structures
in the lamina propria, liver parenchyma and alveolar septa were observed. CNS diseases
are rare and sporadic, however, veterinarians and rural producers must know the
clinicopathological characteristics of these diseases to better define controls and
prophylaxis.