Bezerra, M. L. C. T.; http://lattes.cnpq.br/5670501128582006; BEZERRA, Marcela Laís de Carvalho Tavares.
Resumo:
Granular cell tumor is a benign soft tissue neoplasm. The histogenesis of this lesion continues
to be discussed, however recent studies point to an origin from the Schwann cells. The
granularity nature of tumor cells may be the result of cell senescence due to lysosomal
accumulation. The lesion can involve skin and subcutaneous tissue and in the region of the
head and neck, the dorsal surface of the tongue is the most affected site. This work reports a
case of granular cell tumor arising in the dorsal tongue of an 18-year-old brown woman
presenting a solitary, fast-growing, asymptomatic and sessile swelling 2 cm in diameter at
clinical examination. After excisional biopsy, a microscopic analysis of massive and poorly
demarcated proliferation of eosinophilic and polygonal cells presents small central dark
nucleius and abundant granular cytoplasm. Cells were closely associated with muscle
striatum. Immunohistochemistry demonstrated a positive staining for S-100 protein in tumor
cells, allowing the diagnosis of granular cell tumor. After one year of treatment, there is no
relapse.