Repercussão patológica em glândula parótida de ratos acometidos por lesões hepáticas induzidas quimicamente.

Abstract

The liver is vulnerable to a wide variety of metabolic, toxic, microbial, circulatory, and neoplastic insults. The main primary liver diseases are viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease and alcoholic hepatocellular carcinoma In the case of the parotid salivary glands like other salivary glands are sites of inflammation or neoplastic development, emphasizing that the parotid gland is responsible for the increased production of saliva and thirst for higher incidence of injuries. A possible relationship between liver damage and injury of parotid was first described by Sprinzels in 1912 and since then few studies have been conducted in this regard, mostly restricted to case reports over the years. We performed chemical induction of liver damage in rats with the use of carbon tetrachloride substance and make possible a correlation of liver damage with secondary damage involving parotid glands, for performing a histopathological analysis that both the liver as the parotid gland. This research consisted of a descriptive histopathology slides stained in hemtoxilina-eosin (HE) of changes in parotid gland in rats with chemically induced liver injury through of carbon tetrachloride (CCl4), being used for this study 15 male rats (Group Test) and one control case. This study found the relationship between liver disease and the onset of parotid glands, though larger studies are needed to deeper verification about this correlation.